Array CGH technologies and their applications to cancer genomes
نویسندگان
چکیده
منابع مشابه
I-45: FISH and Array CGH for PGD of Cancer
We developed several FISH approaches to enable preimplantation genetic diagnosis of cancer predisposition syndromes. An overview of the applications and the results of those PGDs will be provided. In addition we developed several novel tools to genome wide screen for CNVs and SNPs in single cells. Those technologies are now being applied for polar body, blastomere and blastocyst screening for c...
متن کاملThe array CGH and its clinical applications.
Array comparative genomic hybridization (aCGH) is a technique enabling high-resolution, genome-wide screening of segmental genomic copy number variations (CNVs). It is becoming an essential and a routine clinical diagnostic tool and is gradually replacing cytogenetic methods. Most of the clinically available aCGH platforms are designed to detect aneuploidies, well-characterized microdeletion/mi...
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proteomics refers to the analysis of expression, localization, functions, posttranslational modifications, and interactions of proteins expressed by a genome at a specific condition and at a specific time. current proteomic tools allow large-scale, high-throughput analyses for the detection, identification, and functional investigation of proteome. in this review, we have focused on the proteom...
متن کاملP-243: Prenatal Diagnosis Using Array CGH: Case Presentation
Background: Karyotype analysis has been the standard and reliable procedure for prenatal cytogenetic diagnosis since the 1970s. However, the major limitation remains requirement for cell culture, resulting in a delay of as much as 14 days to get the test results.CGH array technology has proven to be useful in detecting causative genomic imbalances or genetic mutations in as many as 15% of child...
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Background Chromosomal abnormalities are common in embryos from assisted reproductive technology, ranging from 60% abnormal embryos in women
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ژورنال
عنوان ژورنال: Chromosome Research
سال: 2005
ISSN: 0967-3849,1573-6849
DOI: 10.1007/s10577-005-2168-x